Research Associate I- DMPK

The Position

Organization : -

Designation & Level: -

Location: -

Department: -

Key Responsibilities

In Vitro ADME studies

• Read and understand various in vitro ADME protocols
• Conduct in vitro stability (liver microsomes, plasma and in any other relevant matrix, chemical stability) experiments for new chemical entities
• Conduct the following in vitro ADME experiments
• logP, logD, pKa measurements
• CYP induction and inhibition assays
• Permeability determinations (Caco-2, MDCK etc) in relevant cell lines
• CYP phenotyping in purified enzyme systems
• Solubility determinations (kinetic, thermodynamic, simulated fluids)
  

Bioanalysis :

• Read and understand the bioanalysis sections in the study protocols
• LC-MS/MS and HPLC-UV/PDA method development and validation (partial and complete)
• Developing fit-for-purpose LC-MS/MS methods for routine in vitro sample analysis
• Extracting data from the instrument, conducting bioanalytical QC and sharing of report with the stakeholders within the DMPK department
• Experience in handling bioanalytical method development for various matrices with focus on in vitro samples; understanding to handle plasma, blood, various tissues, urine, faeces etc. is a plus but not mandatory.
• Development LC-MS/MS methods for biochemical and cell based screening of NCEs is a plus but not mandatory
• General LC-MS/MS and HPLC maintenance and troubleshooting
  

Data analysis and report generation:

• Understand the quality of bioanalytical data
• Conduct data analysis employing Phoenix WinNonLin software is a plus but not mandatory
• Ability to calculate in vitro results/ parameters on excel spreadsheets
• Report generation (excel format, word format and PowerPoint presentation) and sharing with the line manager
  

Person Profile

Qualification: -

• M.Sc /M.Tech (Biochemistry, Pharmaceutical Chemistry, Biotech background)
• Master in Pharmacy (M.Pharm)
  

Experience: -

• 2- 6 years of relevant experience.
• Experience in a drug discovery industry/ CRO in DMPK department.
  

Jubilant is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, colour, gender identity or expression, genetic information, marital status, medical condition, national origin, political affiliation, race, ethnicity, religion or any other characteristic protected by applicable local laws, regulations and ordinances.