3 Metabolic Stability Jobs

Role & responsibilities Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Preferred candidate profile A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research.

As an In vitro ADME Scientist at Syngene, your primary responsibility will be to support the ADME team by planning and conducting metabolic stability, Single point inhibition, reversible CYPIC50 inhibition, and TDI-IC50 shift assays using Human liver microsomes with the highest quality. Your role will require excellent time management and multitasking skills to meet the demands of high-volume ADME assays and complete multiple projects within specified timelines. This predominantly laboratory-based position necessitates contemporaneous recording of lab activities, adherence to safety rules, and maintenance of a safe workplace environment. Key responsibilities of the role include extensive experience in planning metabolic stability and CYP inhibition assays, designing and executing in-vitro Single point inhibition, reversible CYPIC50 inhibition, and TDI-IC50 shift assays with human liver microsomes. You will be expected to coordinate seamlessly with the BA-DMPK group, prepare SOPs and EOPs, report executed studies without any noncompliance, and present study results clearly in cross-functional scientific meetings. It is imperative to follow environment, health, and safety (EHS) requirements at all times in the workplace to ensure individual and lab/plant safety. The position requires candidates to hold an M Pharm. in any pharmaceutical science or M Sc. in biological science. Additionally, a comprehensive understanding of in vitro ADME assays, technical expertise in troubleshooting the assays, and a good knowledge of software tools such as Microsoft Excel and GraphPad Prism are essential. Demonstrated cross-functional leadership capabilities, experience with automation, and a minimum of six years of industrial experience in DMPK/ADME research are preferred qualifications. Behavioral skills expected from the candidate include the ability to be a team player, commitment to delivering study reports within agreed timelines, adaptability to changes in a dynamic lab environment, and effective communication with colleagues and collaborators during meetings and presentations. Syngene is an Equal Opportunity Employer, fostering a corporate culture that values diversity and inclusivity.,

Job Title: ADME Scientist Job Location: Bangalore/Hyderabad Department: Discovery Biology About Syngene Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation. Job Purpose Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines. Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping Adhere to all safety rules and maintains safe workplace. Predominantly laboratory-based job Key Responsibilities: Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Educational Qualification: A M Pharm. in any pharmaceutical science or M Sc. in biological science. Technical/functional Skills: Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism Demonstrated cross functional leadership capabilities Experience with automation is desirable Experience: A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research. Behavioral Skills: Demonstrate ability to be a team player. Commitment to deliver the study reports within the agreed timelines Adaptability to changes in the dynamic lab environment Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.